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A Time for Metabolism and Hormones by Paolo Sassone-Corsi, Yves Christen

By Paolo Sassone-Corsi, Yves Christen

Recent years have obvious dazzling advances within the box of circadian biology. those have attracted the curiosity of researchers in lots of fields, together with endocrinology, neurosciences, melanoma, and behaviour. via integrating a circadian view in the fields of endocrinology and metabolism, researchers should be capable of demonstrate many, yet-unsuspected points of ways organisms focus on alterations within the surroundings and next keep an eye on of homeostasis. This box is starting new avenues in our knowing of metabolism and endocrinology. A panel of the main exclusive investigators within the box amassed jointly to debate the current nation and the way forward for the sector. The editors belief that this quantity could be of use to these colleagues who might be picking out up the problem to solve how the circadian clock could be distinct for the longer term improvement of particular pharmacological suggestions towards a few pathologies.

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Science 280:1564–1569 Guenther MG, Levine SS, Boyer LA, Jaenisch R, Young RA (2007) A chromatin landmark and transcription initiation at most promoters in human cells. Cell 130:77–88 Hennig S, Strauss H, Vanselow K, Yildiz O, Schulze S, Arens J, Kramer A, Wolf E (2009) Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2. PLoS Biol 7:e94 Hong HK, Chong JL, Song W, Song EJ, Jyawook AA, Schook AC, Ko CH, Takahashi JS (2007) Inducible and reversible Clock gene expression in brain using the tTA system for the study of circadian behavior.

Introduction Circadian clocks regulate and coordinate rhythms in behavior, physiology, biochemistry and gene expression in mammals (Pittendrigh 1981a, b; Akhtar et al. 2002; Panda et al. 2002; Storch et al. 2002; Ueda et al. 2002; Duffield 2003; Welsh et al. 2004; Reddy et al. 2006), allowing animals to synchronize appropriately to the environmental light:dark cycles. The mammalian circadian clock is composed of an intracellular feedback mechanism in which interlocking transcriptional-translational feedback loops generate the 24-h rhythms (reviewed in Lowrey and Takahashi 2004; Takahashi et al.

Our work also showed that cells exhibit an autonomous rhythm of oxygen consumption, glucose oxidation, and mitochondrial lipid catabolism. Importantly, the oxygen consumption cycle in muscle is directly linked to metabolism of NAD+ and activity of the mitochondrial NAD+-dependent deacetylase SIRT3 (Peek et al. 2013). 28 J. Bass Although the aforementioned work has pinpointed specific defects in clock control of mitochondrial function, several unanswered questions remain in dissecting the effect of clock-NAD+ rhythms on physiology and cell biology.

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