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Advanced Pathology and Treatment of Diseases of Domestic by C.D.N. Singh

By C.D.N. Singh

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Sulfonamides are effective in treating glanders in man and laboratory animals. Penicillin and streptomycin are not effective. Horses can be treated for atleast 20 days with sulpha drugs. The treatment of glanders is not advisable in view of threat to public health. In order to control glanders in horses, the best procedure is to test horses for glanders and destroy the positive cases. The mallein test and complement fixation are done in horses to diagnose glanders. Leptospi rosis A bacterial disease of man and animals caused by organisms of the genus Leptospira icterohaemorrhagiae.

Such changes at the centre of the tubercle are accompanied by proliferation of the fibroblasts 47 Advanced Pathology and Treatment of Diseases of Domes tic Animals at the periphery of the h~sions in order to encapsulate the TB lesions. Encapsulation tends to isolate the disease processes and limits their spread into healthy tissues or other organs. Diagnosis It is based on the following : Symptoms, lesions and detection and isolation of M. tuberculosis from tuberculous lesions. TB bacilli are found in the smears made from the coughed up mucus, milk sediment, vaginal discharge, urine and faeces etc.

Leptospirae can be found within sinusoids of liver cells by silver impregnation technique. There is almost no change in the glomeruli of the kidneys but the epithelial cells of the convoluted tubules are swollen, granular and highly eosinophilic. These epithelial cells may be vacuolated or desquamated into the tubular lumens. The basement membrane of the tubules can be seen in some cases and the tubular lumina can be found packed with eosinophilic epithelial cytoplasmic debris which may show nuclei with occasional presence of some red cells: The tubular epithelial cells may show regenerative changes which are evidenced by the presence of mitoses, hyperchromatic nuclei or multinucleated giant cells (due to fusion or coalescence of the cells).

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