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AMP-activated Protein Kinase by Mario D. Cordero, Benoit Viollet

By Mario D. Cordero, Benoit Viollet

AMPK has emerged as an immense integrator of signs that regulate power stability during the rules of a number of biochemical pathways in eukaryotes.

This e-book makes a speciality of the results of AMPK as a grasp metabolic regulator in illnesses, together with new equipment and animal types. The contributions are written by way of best specialists within the box and provides an intensive evaluation of the present wisdom of AMPK biology and the position of AMPK in overall healthiness and affliction.

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PGC-1α exerts these effects by binding and co-activating other transcriptional factor and/or nuclear receptors to increase their expression such as ERRα, NRF1 and NRF2, and MEF2 and PPARα (Handschin and Spiegelman 2006; Vega et al. 2000). AMPK can activate PGC-1α by phosphorylation or increase its expression (Jager et al. 2007). AMPK also activates PGC-1α through its deacetylation via SIRT1, and PGC-1α deacetylation is associated with the induction of its target genes such as CPT1, pyruvate dehydrogenase kinase 4 (PDK4), or GLUT4 (Canto et al.

PLoS One 3(3):e1797, Pubmed Central PMCID: 2258435, Epub 2008/03/13. eng Koonen DP, Glatz JF, Bonen A, Luiken JJ (2005) Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle. Biochim Biophys Acta 1736(3):163–180, Epub 2005/10/04. eng Kramer HF, Witczak CA, Fujii N, Jessen N, Taylor EB, Arnolds DE et al (2006) Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle. Diabetes 55(7):2067–2076, Epub 2006/06/29.

6 AMPK in Protein Turnover . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 25 26 28 29 29 30 30 30 31 33 34 34 37 Abstract This chapter summarizes AMPK function in the regulation of substrate and energy metabolism with the main emphasis on carbohydrate and lipid metabolism, protein turnover, mitochondrial biogenesis, and whole-body energy homeostasis.

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